|The gout demon 1799|
This leaves humans vulnerable to the accumulation of urea in their bodies. This condition is known as gout.
One treatment for gout is the artificial provision of uricase (made by Aspergillus), however once injected the enzyme is rapidly broken down by our immune system as it is quickly recognised as a 'non-human' protein. Researchers are investigating attaching the enzyme to a large 'protective' molecule such as polyethylene glycol (PEG) in order to extend its half life and improve efficacy. Success has been limited but useful.