The report concludes that there are almost 10 million people under the age of 45 living with asthma in Europe, of which approximately 1 million have severe asthma which difficult to manage clinically. It is thought that around 50% of patients with severe asthma have sensitisation to various fungi (SAFS), of which Aspergillus fumigatus is the most common.
Moderate or severe COPD is present in 5-10% of the European population (25-50 million people). This results in around 300,000 deaths in Europe every year. The majority of this burden comes from lifelong cigarette smokers, of which 40-50% will develop COPD in their lifetime. Invasive aspergillosis in COPD is thought to affect about 1.2% of the 3,600,000 people admitted to hospital each year; about 34,000 people. It carries an 85% mortality. Chronic pulmonary aspergillosis also affects COPD patients.
Previously the prevalence of cystic fibrosis in the EU was estimated at around 37,000 cases. Allergic bronchopulmonary aspergillosis (ABPA) affects about 15% of teenagers and adults with cystic fibrosis. The report summarises that 15% of these patients are hospitalised at least once per year. Approximately 200 people with CF will undergo a lung transplant every year, although this figure is rising.
Interstitial lung diseases (ILD) are a collection of over 300 diseases, but mostly made up of idiopathic pulmonary fibrosis and sarcoidosis. Together they account for 50% of all ILDs in Europe, with hospitalisation and death rates peaking at 40 and 2.5 per 100,000 respectively. Aspergillosis is a common complication of fibrosing sarcoidosis, with a predicted prevalence of almost 166,000 people in Europe.
The total economic burden of respiratory disease was estimated at €379.6 billion, with COPD and asthma causing over €200 billion of this.