Friday, 13 September 2013

ICAAC 2013: Invasive Mycoses: Consider the Source, Consider the Host

Introduction and Overview of Host Issues


  • HSCT Patient with a Mold Infection
  • Pediatric Patient with a Fever in the Pediatric ICU
  • SOT Patient with Suspected Fungal Infection

Program Overview
Invasive fungal infections (IFIs) remain a substantial source of morbidity and mortality. While the increasing burden of IFIs is generally seen as a byproduct of modern medicine and an increasing net state of immunosuppression, emerging data on genomics and the immunologic response of the host are informing a deeper understanding of what happens at the level of the patient. This activity will address the differences in IFIs among pediatric patients, solid organ transplant (SOT) patients, and hematopoietic stem cell transplant (HSCT) patients in terms of causative pathogens (the source), the host response to the pathogens, diagnostic considerations, and response to therapeutic interventions.

This activity will explore whether our increased understanding of these interrelated factors can lead to personalized therapy for IFIs, as is occurring in oncology. Against this backdrop, we have documented gaps in managing IFIs per evidence-based society guidelines, such as in initiating prophylactic, pre-emptive, and empiric therapy (when appropriate) and definitive treatment across these host types. Finally, as emerging diagnostics and therapeutics are developed, their efficacy in these varied host populations as well as their interactions with host factors are key considerations. All of these topics will also be addressed in this initiative using a case-based, interactive format.

More details posted here when available

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