Monday, 29 August 2011

NewsBite: Molecular mechanism of Aspergillus fumigatus adherence to host constituents

Inhaled conidia of Aspergillus fumigatus rapidly adhere to pulmonary epithelial cells and other host constituents. Identifying molecular mechanisms underlying A. fumigatus adherence has therefore been the focus of a number of studies aimed at identifying novel therapeutic targets.
Recent advances have suggested an important role for fungal carbohydrate components of the cell wall and extracellular matrix in adherence, including sialic acid and mannose residues, and the
newly described polysaccharide galactosaminogalactan. Read more

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