"Invasive fungal diseases often take hold when a person’s natural defenses are weakened. These infections frequently occur in hospital settings, after a patient’s normal bacterial flora is wiped out by antibiotics, or the skin and gut mucosa are breached by surgery or central venous catheters including for intravenous nutrition. In fact, candidiasis, an infection caused by one of several species of the yeast Candida, is now the fourth most common bloodstream infection in hospitalized patients both in the
So where does that leave us with respect to Aspergillus infection - the second most common cause of hospital acquired invasive fungal infection ? It is more of a challenge to develop a vaccine for Aspergillosis since virtually all patients with invasive illness are highly immunocompromised. The risk factors for aspergillosis include white cell depletion from chemotherapy, leukaemia or bone marrow transplant and long term corticosteroid or immunosuppressant treatment. Since the infections tend to set in after multiple weeks of an at - risk situation - the suggestion that clinicians could vaccinate before infection sets in - is promising.