Monday, 27 June 2011

NewsBites: What makes Aspergillus fumigatus such a good pathogen?

Aspergillus fumigatus is usually described as requiring good levels of oxygen to support growth. However when growing as a pathogen in a human body there are poor levels of available oxygen - hypoxic conditions.
A recent report in the Journal of Proteome Research,
"The mold Aspergillus fumigatus is the most important airborne fungal pathogen. Adaptation to hypoxia represents an important virulence attribute for A. fumigatus. Therefore, we aimed at obtaining a comprehensive overview about this process on the proteome level."
This led to "identiļ¬cation of 117 proteins with an altered abundance under hypoxic in comparison to normoxic conditions."
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