Monday, 6 July 2009

FDA revise guidelines for rheumatoid arthritis drug Leflunomide


The Food and Drug Administration (FDA) in the United States has issued a safety update for a drug used to treat active rheumatoid arthritis. They now recommend that all patients must be screened for tuberculosis and other pulmonary infections such as aspergillosis prior to taking Leflunomide due to the risk that the drug will increase the chances that these infections will get worse.

Medications with immunosuppressive potential, such as leflunomide, may increase patient susceptibility to opportunistic infections, particularly tuberculosis (including extrapulmonary disease), Pneumocystis jiroveci pneumonia, and aspergillosis.

The FDA notes that leflunomide has not been studied in patients with a positive tuberculin screen result, and the safety of leflunomide in those with latent infection remains unknown. Patients with a positive test result should be treated by standard medical practice before starting leflunomide therapy.

Leflunomide is indicated to reduce signs and symptoms of disease, inhibit structural damage, and improve physical function in patients with active rheumatoid arthritis.

3 comments:

Kishorte said...

Here is some additional information about the "genetics" of this condition that was written by our Genetic Counselor and other genetic professionals: http://www.accessdna.com/condition/Rheumatoid_Arthritis/328. I hope it helps. Thanks, AccessDNA

Bristoll Cardiff said...

You are now talking health reform will be changed soon; we trust that Obama and his staff do what is necessary for the welfare of families. This reform must be appropriate because many families depend on it, the health system a long time that is weak and patients suffering from cancer, chronic fibromyalgia, rheumatoid arthritis, Parkinson's, diabetes, chronic pain, chronic anxiety among many other diseases, Need proper medical attention, according to the measure should be findrxonline for 80% of patients with these diseases.

"Guppy" Honaker said...

My son-in-law served an LDS mission in the Philippines. He got TB there (happily, he is perfectly healthy many years later). A lot of people in 3rd world countries have - or have been exposed to - TB. This is an important drug warning for so many people. Thanks for posting it.

- David

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